8FPI

Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1

8FPI の概要

• エントリーDOI: 10.2210/pdb8fpi/pdb
• EMDBエントリー: 29365
• 分子名称: RNA-directed RNA polymerase L, Phosphoprotein, 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide (3 entities in total)
• 機能のキーワード: rna-binding protein, rsv, rdrp, rna-dependent rna polymerase, prntase, polyribonucleotidyl transferase, rna capping, viral replication, viral protein, replication
• 由来する生物種: Human respiratory syncytial virus A2; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 289998.02

構造登録者

Fischmann, T.O. (登録日: 2023-01-04, 公開日: 2023-06-14, 最終更新日: 2024-06-19)

• 主引用文献: Kleiner, V.A.,Fischmann, T.O.,Howe, J.A.,Beshore, D.C.,Eddins, M.J.,Hou, Y.,Mayhood, T.,Klein, D.,Nahas, D.D.,Lucas, B.J.,Xi, H.,Murray, E.,Ma, D.Y.,Getty, K.,Fearns, R.; Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases.; Commun Biol, 6:649-649, 2023; PubMed: 37337079; DOI: 10.1038/s42003-023-04990-0

実験手法

ELECTRON MICROSCOPY (2.52 Å)