8FO9

Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 tetramer state

Summary for 8FO9

• Entry DOI: 10.2210/pdb8fo9/pdb
• EMDB information: 29342
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, Ras-related protein Rab-7L1, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: cryo-em, parkinson's disease, kinase, lrrk2, rab gtpases, activation, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 1189990.30

Authors

Zhu, H.,Sun, J. (deposition date: 2022-12-30, release date: 2024-01-03)

• Primary citation: Zhu, H.,Tonelli, F.,Turk, M.,Prescott, A.,Alessi, D.R.,Sun, J.; Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.; Science, 382:1404-1411, 2023; PubMed: 38127736; DOI: 10.1126/science.adi9926

Experimental method

ELECTRON MICROSCOPY (3.48 Å)