8FO9

Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 tetramer state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000149	molecular_function	SNARE binding
A	0000165	biological_process	MAPK cascade
A	0000287	molecular_function	magnesium ion binding
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003779	molecular_function	actin binding
A	0003924	molecular_function	GTPase activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004706	molecular_function	JUN kinase kinase kinase activity
A	0004709	molecular_function	MAP kinase kinase kinase activity
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0005764	cellular_component	lysosome
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005798	cellular_component	Golgi-associated vesicle
A	0005802	cellular_component	trans-Golgi network
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005902	cellular_component	microvillus
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006606	biological_process	protein import into nucleus
A	0006897	biological_process	endocytosis
A	0006914	biological_process	autophagy
A	0006979	biological_process	response to oxidative stress
A	0007005	biological_process	mitochondrion organization
A	0007029	biological_process	endoplasmic reticulum organization
A	0007030	biological_process	Golgi organization
A	0007040	biological_process	lysosome organization
A	0007154	biological_process	cell communication
A	0007165	biological_process	signal transduction
A	0007254	biological_process	JNK cascade
A	0007266	biological_process	Rho protein signal transduction
A	0007283	biological_process	spermatogenesis
A	0007528	biological_process	neuromuscular junction development
A	0008017	molecular_function	microtubule binding
A	0008021	cellular_component	synaptic vesicle
A	0008104	biological_process	protein localization
A	0008340	biological_process	determination of adult lifespan
A	0009267	biological_process	cellular response to starvation
A	0009966	biological_process	regulation of signal transduction
A	0010468	biological_process	regulation of gene expression
A	0010506	biological_process	regulation of autophagy
A	0010508	biological_process	positive regulation of autophagy
A	0010955	biological_process	negative regulation of protein processing
A	0010977	biological_process	negative regulation of neuron projection development
A	0014041	biological_process	regulation of neuron maturation
A	0015631	molecular_function	tubulin binding
A	0016242	biological_process	negative regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016787	molecular_function	hydrolase activity
A	0017075	molecular_function	syntaxin-1 binding
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019722	biological_process	calcium-mediated signaling
A	0021756	biological_process	striatum development
A	0021772	biological_process	olfactory bulb development
A	0022028	biological_process	tangential migration from the subventricular zone to the olfactory bulb
A	0030154	biological_process	cell differentiation
A	0030159	molecular_function	signaling receptor complex adaptor activity
A	0030182	biological_process	neuron differentiation
A	0030276	molecular_function	clathrin binding
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0030672	cellular_component	synaptic vesicle membrane
A	0031267	molecular_function	small GTPase binding
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0031410	cellular_component	cytoplasmic vesicle
A	0031647	biological_process	regulation of protein stability
A	0031966	cellular_component	mitochondrial membrane
A	0032091	biological_process	negative regulation of protein binding
A	0032092	biological_process	positive regulation of protein binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0032839	cellular_component	dendrite cytoplasm
A	0034211	molecular_function	GTP-dependent protein kinase activity
A	0034260	biological_process	negative regulation of GTPase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0034614	biological_process	cellular response to reactive oxygen species
A	0035556	biological_process	intracellular signal transduction
A	0035564	biological_process	regulation of kidney size
A	0035640	biological_process	exploration behavior
A	0035641	biological_process	locomotory exploration behavior
A	0035751	biological_process	regulation of lysosomal lumen pH
A	0036479	molecular_function	peroxidase inhibitor activity
A	0039706	molecular_function	co-receptor binding
A	0040012	biological_process	regulation of locomotion
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043068	biological_process	positive regulation of programmed cell death
A	0043195	cellular_component	terminal bouton
A	0043204	cellular_component	perikaryon
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0044024	molecular_function	histone H2AS1 kinase activity
A	0044325	molecular_function	transmembrane transporter binding
A	0044753	cellular_component	amphisome
A	0044754	cellular_component	autolysosome
A	0045121	cellular_component	membrane raft
A	0045202	cellular_component	synapse
A	0045335	cellular_component	phagocytic vesicle
A	0045746	biological_process	negative regulation of Notch signaling pathway
A	0045860	biological_process	positive regulation of protein kinase activity
A	0046039	biological_process	GTP metabolic process
A	0046777	biological_process	protein autophosphorylation
A	0048312	biological_process	intracellular distribution of mitochondria
A	0048812	biological_process	neuron projection morphogenesis
A	0051018	molecular_function	protein kinase A binding
A	0051646	biological_process	mitochondrion localization
A	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
A	0051900	biological_process	regulation of mitochondrial depolarization
A	0051966	biological_process	regulation of synaptic transmission, glutamatergic
A	0060070	biological_process	canonical Wnt signaling pathway
A	0060079	biological_process	excitatory postsynaptic potential
A	0060159	biological_process	regulation of dopamine receptor signaling pathway
A	0060161	biological_process	positive regulation of dopamine receptor signaling pathway
A	0060628	biological_process	regulation of ER to Golgi vesicle-mediated transport
A	0060828	biological_process	regulation of canonical Wnt signaling pathway
A	0061001	biological_process	regulation of dendritic spine morphogenesis
A	0070062	cellular_component	extracellular exosome
A	0070585	biological_process	protein localization to mitochondrion
A	0070971	cellular_component	endoplasmic reticulum exit site
A	0070973	biological_process	protein localization to endoplasmic reticulum exit site
A	0071287	biological_process	cellular response to manganese ion
A	0071407	biological_process	cellular response to organic cyclic compound
A	0090140	biological_process	regulation of mitochondrial fission
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0090394	biological_process	negative regulation of excitatory postsynaptic potential
A	0097487	cellular_component	multivesicular body, internal vesicle
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099400	cellular_component	caveola neck
A	0099523	cellular_component	presynaptic cytosol
A	0106310	molecular_function	protein serine kinase activity
A	0140058	biological_process	neuron projection arborization
A	0141161	biological_process	regulation of cAMP/PKA signal transduction
A	1900242	biological_process	regulation of synaptic vesicle endocytosis
A	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
A	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A	1902499	biological_process	positive regulation of protein autoubiquitination
A	1902692	biological_process	regulation of neuroblast proliferation
A	1902803	biological_process	regulation of synaptic vesicle transport
A	1902823	biological_process	negative regulation of late endosome to lysosome transport
A	1902902	biological_process	negative regulation of autophagosome assembly
A	1903125	biological_process	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
A	1903215	biological_process	negative regulation of protein targeting to mitochondrion
A	1903217	biological_process	negative regulation of protein processing involved in protein targeting to mitochondrion
A	1903351	biological_process	cellular response to dopamine
A	1903980	biological_process	positive regulation of microglial cell activation
A	1904713	molecular_function	beta-catenin destruction complex binding
A	1904887	biological_process	Wnt signalosome assembly
A	1905279	biological_process	regulation of retrograde transport, endosome to Golgi
A	1905289	biological_process	regulation of CAMKK-AMPK signaling cascade
A	1990904	cellular_component	ribonucleoprotein complex
A	1990909	cellular_component	Wnt signalosome
A	2000172	biological_process	regulation of branching morphogenesis of a nerve
A	2000300	biological_process	regulation of synaptic vesicle exocytosis
A	2000377	biological_process	regulation of reactive oxygen species metabolic process
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0016192	biological_process	vesicle-mediated transport
B	0031982	cellular_component	vesicle
C	0000139	cellular_component	Golgi membrane
C	0000149	molecular_function	SNARE binding
C	0000165	biological_process	MAPK cascade
C	0000287	molecular_function	magnesium ion binding
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0003779	molecular_function	actin binding
C	0003924	molecular_function	GTPase activity
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004706	molecular_function	JUN kinase kinase kinase activity
C	0004709	molecular_function	MAP kinase kinase kinase activity
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0005764	cellular_component	lysosome
C	0005768	cellular_component	endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005798	cellular_component	Golgi-associated vesicle
C	0005802	cellular_component	trans-Golgi network
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005902	cellular_component	microvillus
C	0006338	biological_process	chromatin remodeling
C	0006468	biological_process	protein phosphorylation
C	0006606	biological_process	protein import into nucleus
C	0006897	biological_process	endocytosis
C	0006914	biological_process	autophagy
C	0006979	biological_process	response to oxidative stress
C	0007005	biological_process	mitochondrion organization
C	0007029	biological_process	endoplasmic reticulum organization
C	0007030	biological_process	Golgi organization
C	0007040	biological_process	lysosome organization
C	0007154	biological_process	cell communication
C	0007165	biological_process	signal transduction
C	0007254	biological_process	JNK cascade
C	0007266	biological_process	Rho protein signal transduction
C	0007283	biological_process	spermatogenesis
C	0007528	biological_process	neuromuscular junction development
C	0008017	molecular_function	microtubule binding
C	0008021	cellular_component	synaptic vesicle
C	0008104	biological_process	protein localization
C	0008340	biological_process	determination of adult lifespan
C	0009267	biological_process	cellular response to starvation
C	0009966	biological_process	regulation of signal transduction
C	0010468	biological_process	regulation of gene expression
C	0010506	biological_process	regulation of autophagy
C	0010508	biological_process	positive regulation of autophagy
C	0010955	biological_process	negative regulation of protein processing
C	0010977	biological_process	negative regulation of neuron projection development
C	0014041	biological_process	regulation of neuron maturation
C	0015631	molecular_function	tubulin binding
C	0016242	biological_process	negative regulation of macroautophagy
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016787	molecular_function	hydrolase activity
C	0017075	molecular_function	syntaxin-1 binding
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0018107	biological_process	peptidyl-threonine phosphorylation
C	0019722	biological_process	calcium-mediated signaling
C	0021756	biological_process	striatum development
C	0021772	biological_process	olfactory bulb development
C	0022028	biological_process	tangential migration from the subventricular zone to the olfactory bulb
C	0030154	biological_process	cell differentiation
C	0030159	molecular_function	signaling receptor complex adaptor activity
C	0030182	biological_process	neuron differentiation
C	0030276	molecular_function	clathrin binding
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0030672	cellular_component	synaptic vesicle membrane
C	0031267	molecular_function	small GTPase binding
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031410	cellular_component	cytoplasmic vesicle
C	0031647	biological_process	regulation of protein stability
C	0031966	cellular_component	mitochondrial membrane
C	0032091	biological_process	negative regulation of protein binding
C	0032092	biological_process	positive regulation of protein binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0032839	cellular_component	dendrite cytoplasm
C	0034211	molecular_function	GTP-dependent protein kinase activity
C	0034260	biological_process	negative regulation of GTPase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0034614	biological_process	cellular response to reactive oxygen species
C	0035556	biological_process	intracellular signal transduction
C	0035564	biological_process	regulation of kidney size
C	0035640	biological_process	exploration behavior
C	0035641	biological_process	locomotory exploration behavior
C	0035751	biological_process	regulation of lysosomal lumen pH
C	0036479	molecular_function	peroxidase inhibitor activity
C	0039706	molecular_function	co-receptor binding
C	0040012	biological_process	regulation of locomotion
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042995	cellular_component	cell projection
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043068	biological_process	positive regulation of programmed cell death
C	0043195	cellular_component	terminal bouton
C	0043204	cellular_component	perikaryon
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043406	biological_process	positive regulation of MAP kinase activity
C	0044024	molecular_function	histone H2AS1 kinase activity
C	0044325	molecular_function	transmembrane transporter binding
C	0044753	cellular_component	amphisome
C	0044754	cellular_component	autolysosome
C	0045121	cellular_component	membrane raft
C	0045202	cellular_component	synapse
C	0045335	cellular_component	phagocytic vesicle
C	0045746	biological_process	negative regulation of Notch signaling pathway
C	0045860	biological_process	positive regulation of protein kinase activity
C	0046039	biological_process	GTP metabolic process
C	0046777	biological_process	protein autophosphorylation
C	0048312	biological_process	intracellular distribution of mitochondria
C	0048812	biological_process	neuron projection morphogenesis
C	0051018	molecular_function	protein kinase A binding
C	0051646	biological_process	mitochondrion localization
C	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
C	0051900	biological_process	regulation of mitochondrial depolarization
C	0051966	biological_process	regulation of synaptic transmission, glutamatergic
C	0060070	biological_process	canonical Wnt signaling pathway
C	0060079	biological_process	excitatory postsynaptic potential
C	0060159	biological_process	regulation of dopamine receptor signaling pathway
C	0060161	biological_process	positive regulation of dopamine receptor signaling pathway
C	0060628	biological_process	regulation of ER to Golgi vesicle-mediated transport
C	0060828	biological_process	regulation of canonical Wnt signaling pathway
C	0061001	biological_process	regulation of dendritic spine morphogenesis
C	0070062	cellular_component	extracellular exosome
C	0070585	biological_process	protein localization to mitochondrion
C	0070971	cellular_component	endoplasmic reticulum exit site
C	0070973	biological_process	protein localization to endoplasmic reticulum exit site
C	0071287	biological_process	cellular response to manganese ion
C	0071407	biological_process	cellular response to organic cyclic compound
C	0090140	biological_process	regulation of mitochondrial fission
C	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
C	0090394	biological_process	negative regulation of excitatory postsynaptic potential
C	0097487	cellular_component	multivesicular body, internal vesicle
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099400	cellular_component	caveola neck
C	0099523	cellular_component	presynaptic cytosol
C	0106310	molecular_function	protein serine kinase activity
C	0140058	biological_process	neuron projection arborization
C	0141161	biological_process	regulation of cAMP/PKA signal transduction
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
C	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C	1902499	biological_process	positive regulation of protein autoubiquitination
C	1902692	biological_process	regulation of neuroblast proliferation
C	1902803	biological_process	regulation of synaptic vesicle transport
C	1902823	biological_process	negative regulation of late endosome to lysosome transport
C	1902902	biological_process	negative regulation of autophagosome assembly
C	1903125	biological_process	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
C	1903215	biological_process	negative regulation of protein targeting to mitochondrion
C	1903217	biological_process	negative regulation of protein processing involved in protein targeting to mitochondrion
C	1903351	biological_process	cellular response to dopamine
C	1903980	biological_process	positive regulation of microglial cell activation
C	1904713	molecular_function	beta-catenin destruction complex binding
C	1904887	biological_process	Wnt signalosome assembly
C	1905279	biological_process	regulation of retrograde transport, endosome to Golgi
C	1905289	biological_process	regulation of CAMKK-AMPK signaling cascade
C	1990904	cellular_component	ribonucleoprotein complex
C	1990909	cellular_component	Wnt signalosome
C	2000172	biological_process	regulation of branching morphogenesis of a nerve
C	2000300	biological_process	regulation of synaptic vesicle exocytosis
C	2000377	biological_process	regulation of reactive oxygen species metabolic process
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0005794	cellular_component	Golgi apparatus
D	0005802	cellular_component	trans-Golgi network
D	0016192	biological_process	vesicle-mediated transport
D	0031982	cellular_component	vesicle
E	0000139	cellular_component	Golgi membrane
E	0000149	molecular_function	SNARE binding
E	0000165	biological_process	MAPK cascade
E	0000287	molecular_function	magnesium ion binding
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0003779	molecular_function	actin binding
E	0003924	molecular_function	GTPase activity
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004706	molecular_function	JUN kinase kinase kinase activity
E	0004709	molecular_function	MAP kinase kinase kinase activity
E	0005096	molecular_function	GTPase activator activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005743	cellular_component	mitochondrial inner membrane
E	0005759	cellular_component	mitochondrial matrix
E	0005764	cellular_component	lysosome
E	0005768	cellular_component	endosome
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005798	cellular_component	Golgi-associated vesicle
E	0005802	cellular_component	trans-Golgi network
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0005902	cellular_component	microvillus
E	0006338	biological_process	chromatin remodeling
E	0006468	biological_process	protein phosphorylation
E	0006606	biological_process	protein import into nucleus
E	0006897	biological_process	endocytosis
E	0006914	biological_process	autophagy
E	0006979	biological_process	response to oxidative stress
E	0007005	biological_process	mitochondrion organization
E	0007029	biological_process	endoplasmic reticulum organization
E	0007030	biological_process	Golgi organization
E	0007040	biological_process	lysosome organization
E	0007154	biological_process	cell communication
E	0007165	biological_process	signal transduction
E	0007254	biological_process	JNK cascade
E	0007266	biological_process	Rho protein signal transduction
E	0007283	biological_process	spermatogenesis
E	0007528	biological_process	neuromuscular junction development
E	0008017	molecular_function	microtubule binding
E	0008021	cellular_component	synaptic vesicle
E	0008104	biological_process	protein localization
E	0008340	biological_process	determination of adult lifespan
E	0009267	biological_process	cellular response to starvation
E	0009966	biological_process	regulation of signal transduction
E	0010468	biological_process	regulation of gene expression
E	0010506	biological_process	regulation of autophagy
E	0010508	biological_process	positive regulation of autophagy
E	0010955	biological_process	negative regulation of protein processing
E	0010977	biological_process	negative regulation of neuron projection development
E	0014041	biological_process	regulation of neuron maturation
E	0015631	molecular_function	tubulin binding
E	0016242	biological_process	negative regulation of macroautophagy
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016787	molecular_function	hydrolase activity
E	0017075	molecular_function	syntaxin-1 binding
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0018107	biological_process	peptidyl-threonine phosphorylation
E	0019722	biological_process	calcium-mediated signaling
E	0021756	biological_process	striatum development
E	0021772	biological_process	olfactory bulb development
E	0022028	biological_process	tangential migration from the subventricular zone to the olfactory bulb
E	0030154	biological_process	cell differentiation
E	0030159	molecular_function	signaling receptor complex adaptor activity
E	0030182	biological_process	neuron differentiation
E	0030276	molecular_function	clathrin binding
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0030426	cellular_component	growth cone
E	0030672	cellular_component	synaptic vesicle membrane
E	0031267	molecular_function	small GTPase binding
E	0031398	biological_process	positive regulation of protein ubiquitination
E	0031410	cellular_component	cytoplasmic vesicle
E	0031647	biological_process	regulation of protein stability
E	0031966	cellular_component	mitochondrial membrane
E	0032091	biological_process	negative regulation of protein binding
E	0032092	biological_process	positive regulation of protein binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0032839	cellular_component	dendrite cytoplasm
E	0034211	molecular_function	GTP-dependent protein kinase activity
E	0034260	biological_process	negative regulation of GTPase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034614	biological_process	cellular response to reactive oxygen species
E	0035556	biological_process	intracellular signal transduction
E	0035564	biological_process	regulation of kidney size
E	0035640	biological_process	exploration behavior
E	0035641	biological_process	locomotory exploration behavior
E	0035751	biological_process	regulation of lysosomal lumen pH
E	0036479	molecular_function	peroxidase inhibitor activity
E	0039706	molecular_function	co-receptor binding
E	0040012	biological_process	regulation of locomotion
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042995	cellular_component	cell projection
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043068	biological_process	positive regulation of programmed cell death
E	0043195	cellular_component	terminal bouton
E	0043204	cellular_component	perikaryon
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043406	biological_process	positive regulation of MAP kinase activity
E	0044024	molecular_function	histone H2AS1 kinase activity
E	0044325	molecular_function	transmembrane transporter binding
E	0044753	cellular_component	amphisome
E	0044754	cellular_component	autolysosome
E	0045121	cellular_component	membrane raft
E	0045202	cellular_component	synapse
E	0045335	cellular_component	phagocytic vesicle
E	0045746	biological_process	negative regulation of Notch signaling pathway
E	0045860	biological_process	positive regulation of protein kinase activity
E	0046039	biological_process	GTP metabolic process
E	0046777	biological_process	protein autophosphorylation
E	0048312	biological_process	intracellular distribution of mitochondria
E	0048812	biological_process	neuron projection morphogenesis
E	0051018	molecular_function	protein kinase A binding
E	0051646	biological_process	mitochondrion localization
E	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
E	0051900	biological_process	regulation of mitochondrial depolarization
E	0051966	biological_process	regulation of synaptic transmission, glutamatergic
E	0060070	biological_process	canonical Wnt signaling pathway
E	0060079	biological_process	excitatory postsynaptic potential
E	0060159	biological_process	regulation of dopamine receptor signaling pathway
E	0060161	biological_process	positive regulation of dopamine receptor signaling pathway
E	0060628	biological_process	regulation of ER to Golgi vesicle-mediated transport
E	0060828	biological_process	regulation of canonical Wnt signaling pathway
E	0061001	biological_process	regulation of dendritic spine morphogenesis
E	0070062	cellular_component	extracellular exosome
E	0070585	biological_process	protein localization to mitochondrion
E	0070971	cellular_component	endoplasmic reticulum exit site
E	0070973	biological_process	protein localization to endoplasmic reticulum exit site
E	0071287	biological_process	cellular response to manganese ion
E	0071407	biological_process	cellular response to organic cyclic compound
E	0090140	biological_process	regulation of mitochondrial fission
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0090394	biological_process	negative regulation of excitatory postsynaptic potential
E	0097487	cellular_component	multivesicular body, internal vesicle
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099400	cellular_component	caveola neck
E	0099523	cellular_component	presynaptic cytosol
E	0106310	molecular_function	protein serine kinase activity
E	0140058	biological_process	neuron projection arborization
E	0141161	biological_process	regulation of cAMP/PKA signal transduction
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
E	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E	1902499	biological_process	positive regulation of protein autoubiquitination
E	1902692	biological_process	regulation of neuroblast proliferation
E	1902803	biological_process	regulation of synaptic vesicle transport
E	1902823	biological_process	negative regulation of late endosome to lysosome transport
E	1902902	biological_process	negative regulation of autophagosome assembly
E	1903125	biological_process	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
E	1903215	biological_process	negative regulation of protein targeting to mitochondrion
E	1903217	biological_process	negative regulation of protein processing involved in protein targeting to mitochondrion
E	1903351	biological_process	cellular response to dopamine
E	1903980	biological_process	positive regulation of microglial cell activation
E	1904713	molecular_function	beta-catenin destruction complex binding
E	1904887	biological_process	Wnt signalosome assembly
E	1905279	biological_process	regulation of retrograde transport, endosome to Golgi
E	1905289	biological_process	regulation of CAMKK-AMPK signaling cascade
E	1990904	cellular_component	ribonucleoprotein complex
E	1990909	cellular_component	Wnt signalosome
E	2000172	biological_process	regulation of branching morphogenesis of a nerve
E	2000300	biological_process	regulation of synaptic vesicle exocytosis
E	2000377	biological_process	regulation of reactive oxygen species metabolic process
F	0000139	cellular_component	Golgi membrane
F	0000149	molecular_function	SNARE binding
F	0000165	biological_process	MAPK cascade
F	0000287	molecular_function	magnesium ion binding
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0003779	molecular_function	actin binding
F	0003924	molecular_function	GTPase activity
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004706	molecular_function	JUN kinase kinase kinase activity
F	0004709	molecular_function	MAP kinase kinase kinase activity
F	0005096	molecular_function	GTPase activator activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005743	cellular_component	mitochondrial inner membrane
F	0005759	cellular_component	mitochondrial matrix
F	0005764	cellular_component	lysosome
F	0005768	cellular_component	endosome
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005798	cellular_component	Golgi-associated vesicle
F	0005802	cellular_component	trans-Golgi network
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005902	cellular_component	microvillus
F	0006338	biological_process	chromatin remodeling
F	0006468	biological_process	protein phosphorylation
F	0006606	biological_process	protein import into nucleus
F	0006897	biological_process	endocytosis
F	0006914	biological_process	autophagy
F	0006979	biological_process	response to oxidative stress
F	0007005	biological_process	mitochondrion organization
F	0007029	biological_process	endoplasmic reticulum organization
F	0007030	biological_process	Golgi organization
F	0007040	biological_process	lysosome organization
F	0007154	biological_process	cell communication
F	0007165	biological_process	signal transduction
F	0007254	biological_process	JNK cascade
F	0007266	biological_process	Rho protein signal transduction
F	0007283	biological_process	spermatogenesis
F	0007528	biological_process	neuromuscular junction development
F	0008017	molecular_function	microtubule binding
F	0008021	cellular_component	synaptic vesicle
F	0008104	biological_process	protein localization
F	0008340	biological_process	determination of adult lifespan
F	0009267	biological_process	cellular response to starvation
F	0009966	biological_process	regulation of signal transduction
F	0010468	biological_process	regulation of gene expression
F	0010506	biological_process	regulation of autophagy
F	0010508	biological_process	positive regulation of autophagy
F	0010955	biological_process	negative regulation of protein processing
F	0010977	biological_process	negative regulation of neuron projection development
F	0014041	biological_process	regulation of neuron maturation
F	0015631	molecular_function	tubulin binding
F	0016242	biological_process	negative regulation of macroautophagy
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016787	molecular_function	hydrolase activity
F	0017075	molecular_function	syntaxin-1 binding
F	0018105	biological_process	peptidyl-serine phosphorylation
F	0018107	biological_process	peptidyl-threonine phosphorylation
F	0019722	biological_process	calcium-mediated signaling
F	0021756	biological_process	striatum development
F	0021772	biological_process	olfactory bulb development
F	0022028	biological_process	tangential migration from the subventricular zone to the olfactory bulb
F	0030154	biological_process	cell differentiation
F	0030159	molecular_function	signaling receptor complex adaptor activity
F	0030182	biological_process	neuron differentiation
F	0030276	molecular_function	clathrin binding
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0030672	cellular_component	synaptic vesicle membrane
F	0031267	molecular_function	small GTPase binding
F	0031398	biological_process	positive regulation of protein ubiquitination
F	0031410	cellular_component	cytoplasmic vesicle
F	0031647	biological_process	regulation of protein stability
F	0031966	cellular_component	mitochondrial membrane
F	0032091	biological_process	negative regulation of protein binding
F	0032092	biological_process	positive regulation of protein binding
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0032839	cellular_component	dendrite cytoplasm
F	0034211	molecular_function	GTP-dependent protein kinase activity
F	0034260	biological_process	negative regulation of GTPase activity
F	0034599	biological_process	cellular response to oxidative stress
F	0034614	biological_process	cellular response to reactive oxygen species
F	0035556	biological_process	intracellular signal transduction
F	0035564	biological_process	regulation of kidney size
F	0035640	biological_process	exploration behavior
F	0035641	biological_process	locomotory exploration behavior
F	0035751	biological_process	regulation of lysosomal lumen pH
F	0036479	molecular_function	peroxidase inhibitor activity
F	0039706	molecular_function	co-receptor binding
F	0040012	biological_process	regulation of locomotion
F	0042391	biological_process	regulation of membrane potential
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042995	cellular_component	cell projection
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0043068	biological_process	positive regulation of programmed cell death
F	0043195	cellular_component	terminal bouton
F	0043204	cellular_component	perikaryon
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043406	biological_process	positive regulation of MAP kinase activity
F	0044024	molecular_function	histone H2AS1 kinase activity
F	0044325	molecular_function	transmembrane transporter binding
F	0044753	cellular_component	amphisome
F	0044754	cellular_component	autolysosome
F	0045121	cellular_component	membrane raft
F	0045202	cellular_component	synapse
F	0045335	cellular_component	phagocytic vesicle
F	0045746	biological_process	negative regulation of Notch signaling pathway
F	0045860	biological_process	positive regulation of protein kinase activity
F	0046039	biological_process	GTP metabolic process
F	0046777	biological_process	protein autophosphorylation
F	0048312	biological_process	intracellular distribution of mitochondria
F	0048812	biological_process	neuron projection morphogenesis
F	0051018	molecular_function	protein kinase A binding
F	0051646	biological_process	mitochondrion localization
F	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
F	0051900	biological_process	regulation of mitochondrial depolarization
F	0051966	biological_process	regulation of synaptic transmission, glutamatergic
F	0060070	biological_process	canonical Wnt signaling pathway
F	0060079	biological_process	excitatory postsynaptic potential
F	0060159	biological_process	regulation of dopamine receptor signaling pathway
F	0060161	biological_process	positive regulation of dopamine receptor signaling pathway
F	0060628	biological_process	regulation of ER to Golgi vesicle-mediated transport
F	0060828	biological_process	regulation of canonical Wnt signaling pathway
F	0061001	biological_process	regulation of dendritic spine morphogenesis
F	0070062	cellular_component	extracellular exosome
F	0070585	biological_process	protein localization to mitochondrion
F	0070971	cellular_component	endoplasmic reticulum exit site
F	0070973	biological_process	protein localization to endoplasmic reticulum exit site
F	0071287	biological_process	cellular response to manganese ion
F	0071407	biological_process	cellular response to organic cyclic compound
F	0090140	biological_process	regulation of mitochondrial fission
F	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
F	0090394	biological_process	negative regulation of excitatory postsynaptic potential
F	0097487	cellular_component	multivesicular body, internal vesicle
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0099400	cellular_component	caveola neck
F	0099523	cellular_component	presynaptic cytosol
F	0106310	molecular_function	protein serine kinase activity
F	0140058	biological_process	neuron projection arborization
F	0141161	biological_process	regulation of cAMP/PKA signal transduction
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
F	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
F	1902499	biological_process	positive regulation of protein autoubiquitination
F	1902692	biological_process	regulation of neuroblast proliferation
F	1902803	biological_process	regulation of synaptic vesicle transport
F	1902823	biological_process	negative regulation of late endosome to lysosome transport
F	1902902	biological_process	negative regulation of autophagosome assembly
F	1903125	biological_process	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
F	1903215	biological_process	negative regulation of protein targeting to mitochondrion
F	1903217	biological_process	negative regulation of protein processing involved in protein targeting to mitochondrion
F	1903351	biological_process	cellular response to dopamine
F	1903980	biological_process	positive regulation of microglial cell activation
F	1904713	molecular_function	beta-catenin destruction complex binding
F	1904887	biological_process	Wnt signalosome assembly
F	1905279	biological_process	regulation of retrograde transport, endosome to Golgi
F	1905289	biological_process	regulation of CAMKK-AMPK signaling cascade
F	1990904	cellular_component	ribonucleoprotein complex
F	1990909	cellular_component	Wnt signalosome
F	2000172	biological_process	regulation of branching morphogenesis of a nerve
F	2000300	biological_process	regulation of synaptic vesicle exocytosis
F	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGSFGSVYrAayegee............VAVK

Chain	Residue	Details
A	LEU1885-LYS1906

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKphNVLL

Chain	Residue	Details
A	ILE1990-LEU2002

---

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. IGTGgGHILLL

Chain	Residue	Details
A	ILE2427-LEU2437

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	GLY14
D	VAL156
B	SER33
B	ASP63
B	ASN125
B	VAL156
D	GLY14
D	SER33
D	ASP63
D	ASN125

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by S.Typhimurium viral protease GtgE

Chain	Residue	Details
B	GLY41
D	GLY41
E	GLY1341
F	GLY1341

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by LRRK2 => ECO:0000269|PubMed:29212815

Chain	Residue	Details
B	ALA71
D	ALA71
C	LEU1885
C	LYS1906
E	LEU1885
E	LYS1906
F	LEU1885
F	LYS1906

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by LRRK2 => ECO:0000269|PubMed:29212815

Chain	Residue	Details
B	ALA72
D	ALA72
C	GLU2098
C	ASN2295
E	GLU2098
E	ASN2295
F	GLU2098
F	ASN2295

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29212815

Chain	Residue	Details
A	SER910
C	SER910
E	SER910
F	SER910

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30635421

Chain	Residue	Details
A	SER935
C	SER935
E	SER935
F	SER935

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29212815

Chain	Residue	Details
A	SER955
A	SER973
C	SER955
C	SER973
E	SER955
E	SER973
F	SER955
F	SER973

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30635421

Chain	Residue	Details
A	SER1292
C	SER1292
E	SER1292
F	SER1292

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28202711

Chain	Residue	Details
A	SER1444
C	SER1444
E	SER1444
F	SER1444

---