8FMJ
Crystal structure of human KRAS in space group R32
Summary for 8FMJ
Entry DOI | 10.2210/pdb8fmj/pdb |
Descriptor | GTPase KRas, MAGNESIUM ION, GLYCEROL, ... (7 entities in total) |
Functional Keywords | cancer, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 21061.67 |
Authors | Brenner, R.,Landgraf, A.,Gonzalez-Gutierrez, G.,Bum-Erdene, K.,Meroueh, S.O. (deposition date: 2022-12-23, release date: 2023-11-22, Last modification date: 2023-12-06) |
Primary citation | Brenner, R.J.,Landgraf, A.D.,Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62:3206-3213, 2023 Cited by PubMed: 37938120DOI: 10.1021/acs.biochem.3c00378 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.33 Å) |
Structure validation
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