8FJY

Human GAR transformylase in complex with GAR substrate and AGF291 inhibitor

Summary for 8FJY

• Entry DOI: 10.2210/pdb8fjy/pdb
• Descriptor: Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamic acid, ... (4 entities in total)
• Functional Keywords: garftase, purine biosynthesis, monomer, inhibitor, ligase, ligase-inhibitor complex, ligase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23535.74

Authors

Wong-Roushar, J.,Dann III, C.E. (deposition date: 2022-12-20, release date: 2023-09-06)

• Primary citation: Nayeen, M.J.,Katinas, J.M.,Magdum, T.,Shah, K.,Wong, J.E.,O'Connor, C.E.,Fifer, A.N.,Wallace-Povirk, A.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A.; Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.; J.Med.Chem., 66:11294-11323, 2023; PubMed: 37582241; DOI: 10.1021/acs.jmedchem.3c00763

Experimental method

X-RAY DIFFRACTION (2.98 Å)