8FJV
Human GAR transformylase in complex with GAR substrate and AGF362 inhibitor
Summary for 8FJV
Entry DOI | 10.2210/pdb8fjv/pdb |
Descriptor | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | garftase, purine biosynthesis, monomer, inhibitor, ligase, ligase-inhibitor complex, ligase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 23573.78 |
Authors | |
Primary citation | Nayeen, M.J.,Katinas, J.M.,Magdum, T.,Shah, K.,Wong, J.E.,O'Connor, C.E.,Fifer, A.N.,Wallace-Povirk, A.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A. Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. J.Med.Chem., 66:11294-11323, 2023 Cited by PubMed: 37582241DOI: 10.1021/acs.jmedchem.3c00763 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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