8FJV

Human GAR transformylase in complex with GAR substrate and AGF362 inhibitor

8FJV の概要

• エントリーDOI: 10.2210/pdb8fjv/pdb
• 分子名称: Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total)
• 機能のキーワード: garftase, purine biosynthesis, monomer, inhibitor, ligase, ligase-inhibitor complex, ligase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23573.78

構造登録者

Wong-Roushar, J.,Dann III, C.E. (登録日: 2022-12-20, 公開日: 2023-09-06)

• 主引用文献: Nayeen, M.J.,Katinas, J.M.,Magdum, T.,Shah, K.,Wong, J.E.,O'Connor, C.E.,Fifer, A.N.,Wallace-Povirk, A.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A.; Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.; J.Med.Chem., 66:11294-11323, 2023; PubMed: 37582241; DOI: 10.1021/acs.jmedchem.3c00763

実験手法

X-RAY DIFFRACTION (2.69 Å)