8FJT

Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF362 inhibitor

Summary for 8FJT

• Entry DOI: 10.2210/pdb8fjt/pdb
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, ... (6 entities in total)
• Functional Keywords: shmt2, tetramer, glycine synthesis, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 110799.23

Authors

Katinas, J.M.,Dann III, C.E. (deposition date: 2022-12-20, release date: 2023-09-06, Last modification date: 2024-02-07)

• Primary citation: Nayeen, M.J.,Katinas, J.M.,Magdum, T.,Shah, K.,Wong, J.E.,O'Connor, C.E.,Fifer, A.N.,Wallace-Povirk, A.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A.; Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.; J.Med.Chem., 66:11294-11323, 2023; PubMed: 37582241; DOI: 10.1021/acs.jmedchem.3c00763

Experimental method

X-RAY DIFFRACTION (2.47 Å)