8FJN
Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - C2221 space group
Summary for 8FJN
| Entry DOI | 10.2210/pdb8fjn/pdb |
| Related | 8FJM |
| Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... (6 entities in total) |
| Functional Keywords | histone lysine methyltransferase, histone-modifying enzyme, dot1a, trypanosoma brucei, adohcy complex, transferase |
| Biological source | Trypanosoma brucei brucei |
| Total number of polymer chains | 1 |
| Total formula weight | 29851.11 |
| Authors | Frisbie, V.S.,Hashimoto, H.,Debler, E.W. (deposition date: 2022-12-20, release date: 2024-02-07, Last modification date: 2024-09-04) |
| Primary citation | Frisbie, V.S.,Hashimoto, H.,Xie, Y.,De Luna Vitorino, F.N.,Baeza, J.,Nguyen, T.,Yuan, Z.,Kiselar, J.,Garcia, B.A.,Debler, E.W. Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids. Nat Commun, 15:2467-2467, 2024 Cited by PubMed: 38503750DOI: 10.1038/s41467-024-46637-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
