8FJ6

LSD1-CoREST in complex with T108, long soaking

Summary for 8FJ6

• Entry DOI: 10.2210/pdb8fj6/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[7,8-dimethyl-2,4-dioxo-5-{3-[3-(phenylcarbamoyl)phenyl]propanoyl}-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (3 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 112550.22

Authors

Caroli, J.,Mattevi, A. (deposition date: 2022-12-19, release date: 2024-06-26)

• Primary citation: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; to be published,

Experimental method

X-RAY DIFFRACTION (2.63 Å)