8FJ0
Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2
Summary for 8FJ0
Entry DOI | 10.2210/pdb8fj0/pdb |
Descriptor | Evasin P1243, C-C motif chemokine 2 (3 entities in total) |
Functional Keywords | tick, evasin, chemokine, anti-inflammatory, cytokine |
Biological source | Amblyomma americanum (Lone Star tick) More |
Total number of polymer chains | 6 |
Total formula weight | 59650.67 |
Authors | Devkota, S.R.,Bhusal, R.P.,Aryal, P.,Wilce, M.C.J.,Stone, M.J. (deposition date: 2022-12-18, release date: 2023-03-29, Last modification date: 2023-07-26) |
Primary citation | Devkota, S.R.,Aryal, P.,Pokhrel, R.,Jiao, W.,Perry, A.,Panjikar, S.,Payne, R.J.,Wilce, M.C.J.,Bhusal, R.P.,Stone, M.J. Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14:4204-4204, 2023 Cited by PubMed: 37452046DOI: 10.1038/s41467-023-39879-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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