8FIM
Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate
Summary for 8FIM
Entry DOI | 10.2210/pdb8fim/pdb |
Descriptor | DNA dC->dU-editing enzyme APOBEC-3A, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), INOSITOL HEXAKISPHOSPHATE, ... (7 entities in total) |
Functional Keywords | apobec, apobec3a, a3a, apobec3a e72a mutant, cancer, dna, mutation, cytidine deaminase, hairpin dna, dna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 55451.81 |
Authors | Harjes, S.,Jameson, G.B.,Harjes, E.,Filichev, V.V.,Kurup, H.M. (deposition date: 2022-12-16, release date: 2023-09-06) |
Primary citation | Harjes, S.,Kurup, H.M.,Filichev, V.,Harjes, E.,Jameson, G.B. DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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