8FIG
Room-temperature X-ray structure of SARS-CoV-2 main protease double mutant E290A/R298A in complex with GC373
Summary for 8FIG
Entry DOI | 10.2210/pdb8fig/pdb |
Descriptor | 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total) |
Functional Keywords | cysteine protease, homodimer, double mutant, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 1 |
Total formula weight | 34086.88 |
Authors | |
Primary citation | Aniana, A.,Nashed, N.T.,Ghirlando, R.,Coates, L.,Kneller, D.W.,Kovalevsky, A.,Louis, J.M. Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors. Commun Biol, 6:1159-1159, 2023 Cited by PubMed: 37957287DOI: 10.1038/s42003-023-05469-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report