8FIG

Room-temperature X-ray structure of SARS-CoV-2 main protease double mutant E290A/R298A in complex with GC373

Summary for 8FIG

• Entry DOI: 10.2210/pdb8fig/pdb
• Descriptor: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total)
• Functional Keywords: cysteine protease, homodimer, double mutant, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 1
• Total formula weight: 34086.88

Authors

Kovalevsky, A.,Coates, L.,Kneller, D.W. (deposition date: 2022-12-16, release date: 2023-11-22)

• Primary citation: Aniana, A.,Nashed, N.T.,Ghirlando, R.,Coates, L.,Kneller, D.W.,Kovalevsky, A.,Louis, J.M.; Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors.; Commun Biol, 6:1159-1159, 2023; PubMed: 37957287; DOI: 10.1038/s42003-023-05469-8

Experimental method

X-RAY DIFFRACTION (1.75 Å)