8FGE
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 4-(difluoromethyl)-6-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)pyridin-2-amine dihydrochloride
Summary for 8FGE
Entry DOI | 10.2210/pdb8fge/pdb |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor, heme enzyme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhbitor complex, oxidoreductase/oxidoreductase inhbitor |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 1 |
Total formula weight | 50063.97 |
Authors | |
Primary citation | Vasu, D.,Do, H.T.,Li, H.,Hardy, C.D.,Awasthi, A.,Poulos, T.L.,Silverman, R.B. Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem., 66:9934-9953, 2023 Cited by PubMed: 37433128DOI: 10.1021/acs.jmedchem.3c00782 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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