8FDY

Human GAR transformylase in complex with GAR substrate and AGF132 inhibitor

Summary for 8FDY

Entry DOI	10.2210/pdb8fdy/pdb
Descriptor	Phosphoribosylglycinamide formyltransferase, GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]pyridine-2-carbonyl}-L-glutamic acid, ... (4 entities in total)
Functional Keywords	garftas, purine biosynthesis, monomer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	23567.80
Authors	Wong-Roushar, J.,Dann III, C.E. (deposition date: 2022-12-05, release date: 2023-05-10, Last modification date: 2023-05-31)
Primary citation	Tong, N.,Wong-Roushar, J.,Wallace-Povirk, A.,Shah, Y.,Nyman, M.C.,Katinas, J.M.,Schneider, M.,O'Connor, C.,Bao, X.,Kim, S.,Li, J.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A. Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. Acs Pharmacol Transl Sci, 6:748-770, 2023 Cited by PubMed: 37200803 DOI: 10.1021/acsptsci.3c00020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation