8FDX

AGF271 and GAR in complex with human recombinant GARFTase, ligase, purine biosynthesis, transfers formyl group from 10-formyl tetrahydrofolate to glycinamide ribonucleotide (GAR) to form tetrahydrofolate and formyl GAR

Summary for 8FDX

Entry DOI	10.2210/pdb8fdx/pdb
Descriptor	Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total)
Functional Keywords	garftase, ligase, purine biosynthesis, monomer
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	23558.81
Authors	Nyman, M.C.,Wong-Roushar, J.,Dann III, C.E. (deposition date: 2022-12-05, release date: 2023-05-10, Last modification date: 2023-10-25)
Primary citation	Tong, N.,Wong-Roushar, J.,Wallace-Povirk, A.,Shah, Y.,Nyman, M.C.,Katinas, J.M.,Schneider, M.,O'Connor, C.,Bao, X.,Kim, S.,Li, J.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A. Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. Acs Pharmacol Transl Sci, 6:748-770, 2023 Cited by PubMed: 37200803 DOI: 10.1021/acsptsci.3c00020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation