8FDA
Human Cytochrome P450 17A1 in complex with steroidal isonitrile inhibitor
8FDA の概要
エントリーDOI | 10.2210/pdb8fda/pdb |
分子名称 | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, [(1~{R})-1-[(3~{S},5~{S},8~{R},9~{S},10~{S},13~{S},17~{R})-3-methanoyloxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,13,14,15,16,17-hexadecahydrocyclopenta[a]phenanthren-17-yl]ethyl]-methylidyne-azanium, ... (4 entities in total) |
機能のキーワード | cytochrome p450 17a1, cytochrome p450 c17, 17-alpha hydroxylase, 17, 20 lyase, isonitrile, steroid, oxidoreductase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 227571.69 |
構造登録者 | |
主引用文献 | Richard, A.M.,Wong, N.R.,Harris, K.,Sundar, R.,Scott, E.E.,Pochapsky, T.C. Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles. Commun Chem, 6:183-183, 2023 Cited by PubMed: 37660137DOI: 10.1038/s42004-023-00994-3 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
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