8FD8
human 15-PGDH with NADH bound
Summary for 8FD8
Entry DOI | 10.2210/pdb8fd8/pdb |
EMDB information | 29005 |
Descriptor | 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE (2 entities in total) |
Functional Keywords | dehydrogenase, inhibitor, oxidoreductase, oxidoreductase-inhibitor complex |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 57102.99 |
Authors | Huang, W.,Taylor, D. (deposition date: 2022-12-02, release date: 2023-03-08, Last modification date: 2024-06-19) |
Primary citation | Huang, W.,Li, H.,Kiselar, J.,Fink, S.P.,Regmi, S.,Day, A.,Yuan, Y.,Chance, M.,Ready, J.M.,Markowitz, S.D.,Taylor, D.J. Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14:784-784, 2023 Cited by PubMed: 36774348DOI: 10.1038/s41467-023-36463-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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