8FD7

Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin

Summary for 8FD7

• Entry DOI: 10.2210/pdb8fd7/pdb
• EMDB information: 29004 29006 29007 29015
• Descriptor: Voltage-dependent calcium channel subunit alpha-2/delta-1, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, CHOLESTEROL, ... (12 entities in total)
• Functional Keywords: voltage-gated calcium channel, cav alpha2delta, drug binding, gabapentin, membrane protein
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 3
• Total formula weight: 370952.36

Authors

Chen, Z.,Mondal, A.,Minor, D.L. (deposition date: 2022-12-02, release date: 2023-03-22, Last modification date: 2023-07-05)

• Primary citation: Chen, Z.,Mondal, A.,Minor Jr., D.L.; Structural basis for Ca V alpha 2 delta :gabapentin binding.; Nat.Struct.Mol.Biol., 30:735-739, 2023; PubMed: 36973510; DOI: 10.1038/s41594-023-00951-7

Experimental method

ELECTRON MICROSCOPY (3.1 Å)