8FC9
Cryo-EM structure of the human TRPV4 - RhoA, apo condition
Summary for 8FC9
Entry DOI | 10.2210/pdb8fc9/pdb |
EMDB information | 28977 |
Descriptor | Transient receptor potential cation channel subfamily V member 4, Transforming protein RhoA, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | trpv4, rhoa, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 497297.84 |
Authors | Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12, Last modification date: 2024-06-19) |
Primary citation | Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y. TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14:3732-3732, 2023 Cited by PubMed: 37353484DOI: 10.1038/s41467-023-39345-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.75 Å) |
Structure validation
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