8F8E

Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound

Summary for 8F8E

• Entry DOI: 10.2210/pdb8f8e/pdb
• Descriptor: DDB1- and CUL4-associated factor 1, (3P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-3-(4-chloro-2-fluorophenyl)-1H-pyrazole-4-carboxamide, CITRIC ACID, ... (4 entities in total)
• Functional Keywords: wd-repeat, wdr, dcaf1, sgc, transferase, structural genomics, structural genomics consortium, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 72256.50

Authors

Kimani, S.,Li, A.,Dong, A.,Li, Y.,Hutchinson, A.,Seitova, A.,Wilson, B.,Al-Awar, R.,Vedadi, M.,Brown, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2022-11-21, release date: 2023-03-01, Last modification date: 2024-05-22)

• Primary citation: Kimani, S.,Li, A.,Dong, A.,Li, Y.,Hutchinson, A.,Seitova, A.,Wilson, B.,Al-Awar, R.,Vedadi, M.,Brown, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.; Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound; To be published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)