8F85

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM851

Summary for 8F85

• Entry DOI: 10.2210/pdb8f85/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{2-[3-({(6M)-2,4-diamino-6-[2-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid, ... (4 entities in total)
• Functional Keywords: ssgcid, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium ulcerans
• Total number of polymer chains: 1
• Total formula weight: 20255.47

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-21, release date: 2023-12-13, Last modification date: 2024-06-19)

• Primary citation: Lovell, S.,Battaile, K.P.,Staker, B.L.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM851; To be published,

Experimental method

X-RAY DIFFRACTION (1.15 Å)