8F85
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM851
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 173 | 19035.6 | 1 | UniProt (A0PQG8) Pfam (PF00186) In PDB | Mycobacterium ulcerans | |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | 3-{2-[3-({(6M)-2,4-diamino-6-[2-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid | non-polymer | 476.4 | 1 | Chemie (XKI) | |||
4 | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A: 1 - 165 (UniProt: A0PQG8)
PDB | External Database | Details |
---|---|---|
Met -7 | - | expression tag |
Ala -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ser 89 | Cys 89 | engineered mutation |
Ala 96 | Glu 96 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 19035.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1219.9 | |
All* | Total formula weight | 20255.5 |