8F6Y

Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state

Summary for 8F6Y

• Entry DOI: 10.2210/pdb8f6y/pdb
• EMDB information: 28892 28893
• Descriptor: Acetylcholine receptor subunit alpha, CHOLESTEROL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: acetylcholine receptor, nicotinic receptor, torpedo, cys-loop receptor, ion channel, muscle-type nicotinic receptor, transport protein-inhibitor complex, general anesthetic, inhibitor, transport protein/inhibitor
• Biological source: Tetronarce californica (Pacific electric ray); More
• Total number of polymer chains: 5
• Total formula weight: 277887.10

Authors

Goswami, U.,Rahman, M.M.,Teng, J.,Hibbs, R.E. (deposition date: 2022-11-17, release date: 2023-06-07, Last modification date: 2024-01-31)

• Primary citation: Goswami, U.,Rahman, M.M.,Teng, J.,Hibbs, R.E.; Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.; Nat Commun, 14:3169-3169, 2023; PubMed: 37264005; DOI: 10.1038/s41467-023-38827-5

Experimental method

ELECTRON MICROSCOPY (2.79 Å)