8F6P
Rat Cardiac Sodium Channel with Ranolazine Bound
Summary for 8F6P
| Entry DOI | 10.2210/pdb8f6p/pdb |
| EMDB information | 28887 |
| Descriptor | Sodium channel protein type 5 subunit alpha,Green fluorescent protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | ion channel voltage-gated ion channel, membrane protein |
| Biological source | Rattus norvegicus (Norway rat) More |
| Total number of polymer chains | 1 |
| Total formula weight | 223097.60 |
| Authors | Lenaeus, M.J.,Tonggu, L. (deposition date: 2022-11-16, release date: 2023-04-12, Last modification date: 2024-11-13) |
| Primary citation | Lenaeus, M.,Gamal El-Din, T.M.,Tonggu, L.,Zheng, N.,Catterall, W.A. Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine. Nat Cardiovasc Res, 2:587-594, 2023 Cited by PubMed: 39185478DOI: 10.1038/s44161-023-00271-5 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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