8F6P

Rat Cardiac Sodium Channel with Ranolazine Bound

8F6P の概要

• エントリーDOI: 10.2210/pdb8f6p/pdb
• EMDBエントリー: 28887
• 分子名称: Sodium channel protein type 5 subunit alpha,Green fluorescent protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: ion channel voltage-gated ion channel, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 223097.60

構造登録者

Lenaeus, M.J.,Tonggu, L. (登録日: 2022-11-16, 公開日: 2023-04-12, 最終更新日: 2024-11-13)

• 主引用文献: Lenaeus, M.,Gamal El-Din, T.M.,Tonggu, L.,Zheng, N.,Catterall, W.A.; Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine.; Nat Cardiovasc Res, 2:587-594, 2023; PubMed: 39185478; DOI: 10.1038/s44161-023-00271-5

実験手法

ELECTRON MICROSCOPY (3.2 Å)