8F5W

Dihydropyrimidine Dehydrogenase (DPD) C671S Mutant Soaked with Dihydrothymine and NADPH Quasi-Anaerobically

Summary for 8F5W

Entry DOI	10.2210/pdb8f5w/pdb
Descriptor	Dihydropyrimidine dehydrogenase [NADP(+)], IRON/SULFUR CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total)
Functional Keywords	dihydropyrimidine dehydrogenase, protein, mutant, dihyrdothymine, nadph, flavoprotein
Biological source	Sus scrofa (pig)
Total number of polymer chains	4
Total formula weight	460429.08
Authors	Kaley, N.,Smith, M.,Forouzesh, D.,Liu, D.,Moran, G. (deposition date: 2022-11-15, release date: 2023-02-01, Last modification date: 2023-10-25)
Primary citation	Smith, M.M.,Forouzesh, D.C.,Kaley, N.E.,Liu, D.,Moran, G.R. Mammalian dihydropyrimidine dehydrogenase: Added mechanistic details from transient-state analysis of charge transfer complexes. Arch.Biochem.Biophys., 736:109517-109517, 2023 Cited by PubMed: 36681231 DOI: 10.1016/j.abb.2023.109517 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation