8F55

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis H37Rv in complex with inhibitor SGT1614

Summary for 8F55

• Entry DOI: 10.2210/pdb8f55/pdb
• Descriptor: N-acetyltransferase Eis, (2E)-2-[(4-chlorophenyl)methylidene]hydrazine-1-carboximidamide, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: drug resistance, acetylation, histone, inhibition, aminoglycoside, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 1
• Total formula weight: 47125.08

Authors

Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2022-11-11, release date: 2023-02-01, Last modification date: 2023-10-25)

• Primary citation: Pang, A.H.,Green, K.D.,Punetha, A.,Thamban Chandrika, N.,Howard, K.C.,Garneau-Tsodikova, S.,Tsodikov, O.V.; Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.; Biochemistry, 62:710-721, 2023; PubMed: 36657084; DOI: 10.1021/acs.biochem.2c00658

Experimental method

X-RAY DIFFRACTION (2.2 Å)