8EZ1
Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid
Summary for 8EZ1
Entry DOI | 10.2210/pdb8ez1/pdb |
Descriptor | Ornithine aminotransferase, mitochondrial, (3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic acid, (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid, ... (4 entities in total) |
Functional Keywords | hoat, oat, inactivator, 3-amino-4-fluorocyclopentenecarboxylic acid, covalent modification, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 135647.75 |
Authors | Butrin, A.,Shen, S.,Silverman, R.,Liu, D. (deposition date: 2022-10-30, release date: 2023-02-22, Last modification date: 2024-03-13) |
Primary citation | Shen, S.,Butrin, A.,Beaupre, B.A.,Ferreira, G.M.,Doubleday, P.F.,Grass, D.H.,Zhu, W.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules, 28:-, 2023 Cited by PubMed: 36770800DOI: 10.3390/molecules28031133 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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