8EZ1

Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid

Summary for 8EZ1

Entry DOI	10.2210/pdb8ez1/pdb
Descriptor	Ornithine aminotransferase, mitochondrial, (3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic acid, (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid, ... (4 entities in total)
Functional Keywords	hoat, oat, inactivator, 3-amino-4-fluorocyclopentenecarboxylic acid, covalent modification, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	135647.75
Authors	Butrin, A.,Shen, S.,Silverman, R.,Liu, D. (deposition date: 2022-10-30, release date: 2023-02-22, Last modification date: 2024-03-13)
Primary citation	Shen, S.,Butrin, A.,Beaupre, B.A.,Ferreira, G.M.,Doubleday, P.F.,Grass, D.H.,Zhu, W.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules, 28:-, 2023 Cited by PubMed: 36770800 DOI: 10.3390/molecules28031133 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation