8EYN

Crystal Structure of Human Mitochondrial NADP+ Malic Enzyme 3 in Apo Form

Summary for 8EYN

• Entry DOI: 10.2210/pdb8eyn/pdb
• Descriptor: NADP-dependent malic enzyme, mitochondrial, CITRIC ACID (3 entities in total)
• Functional Keywords: oxidoreductase, malic enzyme, rossmann fold, me3, nadp(+)-binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 128042.95

Authors

Shaffer, P.L.,Grell, T.A.J.,Mason, M.,Thompson, A.A.,Riley, D.,Wagner, M.V.,Steele, R.,Ortiz-Meoz, R.,Wadia, J.,Sharma, S.,Yu, X. (deposition date: 2022-10-28, release date: 2023-02-08, Last modification date: 2023-10-25)

• Primary citation: Grell, T.A.J.,Mason, M.,Thompson, A.A.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Steele, R.,Ortiz-Meoz, R.F.,Wadia, J.,Shaffer, P.L.,Tresadern, G.,Sharma, S.,Yu, X.; Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.; Heliyon, 8:e12392-e12392, 2022; PubMed: 36590518; DOI: 10.1016/j.heliyon.2022.e12392

Experimental method

X-RAY DIFFRACTION (1.94 Å)