8EYL

Human Carbonic Anhydrase II with Tert-butyl (2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)carbamate

Summary for 8EYL

Entry DOI	10.2210/pdb8eyl/pdb
Related	8EMU 8EXC 8EXG
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (5 entities in total)
Functional Keywords	targeted protein degrader, protac, metalloenzyme, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30835.33
Authors	Kohlbrand, A.J.,O'Herin, C.B. (deposition date: 2022-10-27, release date: 2023-02-22, Last modification date: 2023-10-25)
Primary citation	O'Herin, C.B.,Moriuchi, Y.W.,Bemis, T.A.,Kohlbrand, A.J.,Burkart, M.D.,Cohen, S.M. Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023 Cited by PubMed: 36735827 DOI: 10.1021/acs.jmedchem.2c01843 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.18 Å)

Structure validation