8EWY
Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Summary for 8EWY
Entry DOI | 10.2210/pdb8ewy/pdb |
EMDB information | 28649 |
Descriptor | Tyrosine-protein kinase, Interferon lambda receptor 1, ADENOSINE, ... (4 entities in total) |
Functional Keywords | jak, kinase, cytokine, signaling protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 293233.32 |
Authors | Caveney, N.A.,Saxton, R.A.,Waghray, D.,Garcia, K.C. (deposition date: 2022-10-24, release date: 2023-03-08, Last modification date: 2023-03-22) |
Primary citation | Caveney, N.A.,Saxton, R.A.,Waghray, D.,Glassman, C.R.,Tsutsumi, N.,Hubbard, S.R.,Garcia, K.C. Structural basis of Janus kinase trans-activation. Cell Rep, 42:112201-112201, 2023 Cited by PubMed: 36867534DOI: 10.1016/j.celrep.2023.112201 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (5.5 Å) |
Structure validation
Download full validation report