8EQ5
Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160)
Summary for 8EQ5
Entry DOI | 10.2210/pdb8eq5/pdb |
Descriptor | Ribosomal protein S6 kinase alpha-3, Sprouty-related, EVH1 domain-containing protein 2, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, ... (4 entities in total) |
Functional Keywords | kinase, spred, complex, cell signaling, erk/mek pathway, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 38764.48 |
Authors | Bonsor, D.A.,Lopez, J.,McCormick, F.,Simanshu, D.K. (deposition date: 2022-10-07, release date: 2023-04-26, Last modification date: 2023-10-25) |
Primary citation | Lopez, J.,Bonsor, D.A.,Sale, M.J.,Urisman, A.,Mehalko, J.L.,Cabanski-Dunning, M.,Castel, P.,Simanshu, D.K.,McCormick, F. The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J.Biol.Chem., 299:104789-104789, 2023 Cited by PubMed: 37149146DOI: 10.1016/j.jbc.2023.104789 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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