8EQ5

Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160)

8EQ5 の概要

• エントリーDOI: 10.2210/pdb8eq5/pdb
• 分子名称: Ribosomal protein S6 kinase alpha-3, Sprouty-related, EVH1 domain-containing protein 2, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, ... (4 entities in total)
• 機能のキーワード: kinase, spred, complex, cell signaling, erk/mek pathway, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38764.48

構造登録者

Bonsor, D.A.,Lopez, J.,McCormick, F.,Simanshu, D.K. (登録日: 2022-10-07, 公開日: 2023-04-26, 最終更新日: 2023-10-25)

• 主引用文献: Lopez, J.,Bonsor, D.A.,Sale, M.J.,Urisman, A.,Mehalko, J.L.,Cabanski-Dunning, M.,Castel, P.,Simanshu, D.K.,McCormick, F.; The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.; J.Biol.Chem., 299:104789-104789, 2023; PubMed: 37149146; DOI: 10.1016/j.jbc.2023.104789

実験手法

X-RAY DIFFRACTION (1.8 Å)