8EPW
Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Summary for 8EPW
Entry DOI | 10.2210/pdb8epw/pdb |
Related | 8EBZ |
Descriptor | GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total) |
Functional Keywords | kras, ras, k-ras, kras4b, raf1, craf, rbd, ras-binding domain, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 29040.00 |
Authors | Tran, T.H.,Chan, A.H.,Dharmaiah, S.,Simanshu, D.K. (deposition date: 2022-10-06, release date: 2023-06-07, Last modification date: 2023-10-25) |
Primary citation | Chao, F.A.,Chan, A.H.,Dharmaiah, S.,Schwieters, C.D.,Tran, T.H.,Taylor, T.,Ramakrishnan, N.,Esposito, D.,Nissley, D.V.,McCormick, F.,Simanshu, D.K.,Cornilescu, G. Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D . Commun Biol, 6:594-594, 2023 Cited by PubMed: 37268708DOI: 10.1038/s42003-023-04960-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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