8EPH

Crystal structure of human coagulation factor IXa (S195A), apo-form, DES-GLA

Summary for 8EPH

Entry DOI	10.2210/pdb8eph/pdb
Descriptor	Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, alpha-L-fucopyranose, ... (5 entities in total)
Functional Keywords	coagulation factor ix, apo form, hydrolase, blood clotting
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	75471.61
Authors	Kolyadko, V.N.,Krishnaswamy, S. (deposition date: 2022-10-05, release date: 2024-07-03, Last modification date: 2024-07-24)
Primary citation	Kolyadko, V.N.,Layzer, J.M.,Perry, K.,Sullenger, B.A.,Krishnaswamy, S. An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa. Proc.Natl.Acad.Sci.USA, 121:e2401136121-e2401136121, 2024 Cited by PubMed: 38985762 DOI: 10.1073/pnas.2401136121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation