8EPH

Crystal structure of human coagulation factor IXa (S195A), apo-form, DES-GLA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Coagulation factor IXa light chain	polymer	102	11316.7	2	UniProt (P00740) Pfam (PF00008) Pfam (PF14670) In PDB	Homo sapiens (human)
2	B, D	Coagulation factor IXa heavy chain	polymer	235	26174.8	2	UniProt (P00740) Pfam (PF00089) In PDB	Homo sapiens (human)
3	A, C	alpha-L-fucopyranose	non-polymer		164.2	2	Chemie (FUC)
4	A, B, C, D	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
5		water	water		18.0	464	Chemie (HOH)

Sequence modifications

A, C: 47 - 144 (UniProt: P00740)

PDB	External Database	Details
Arg 145	-	insertion
Arg 146	-	insertion
Lys 147	-	insertion
Arg 148	-	insertion

B, D: 16 - 245 (UniProt: P00740)

PDB	External Database	Details
Ala 195	Ser 411	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	74983.0
Non-Polymers*	Number of molecules	6
	Total formula weight	488.6
All*	Total formula weight	75471.6

*Water molecules are not included.