8EPH
Crystal structure of human coagulation factor IXa (S195A), apo-form, DES-GLA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Coagulation factor IXa light chain | polymer | 102 | 11316.7 | 2 | UniProt (P00740) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | |
| 2 | B, D (B, D) | Coagulation factor IXa heavy chain | polymer | 235 | 26174.8 | 2 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | E, H (A, C) | alpha-L-fucopyranose | non-polymer | 164.2 | 2 | Chemie (FUC) | |||
| 4 | F, G, I, J (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 464 | Chemie (HOH) |
Sequence modifications
A, C: 47 - 144 (UniProt: P00740)
B, D: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Arg 145 | - | insertion |
| Arg 146 | - | insertion |
| Lys 147 | - | insertion |
| Arg 148 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74983.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 488.6 | |
| All* | Total formula weight | 75471.6 |
