8EOP

Cryo-EM Structure of Nanodisc reconstituted human ABCA7 EQ mutant in ATP bound closed state

Summary for 8EOP

Entry DOI	10.2210/pdb8eop/pdb
EMDB information	28451
Descriptor	Phospholipid-transporting ATPase ABCA7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	abc transporter, lipid transporter, abc exporter, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	237997.77
Authors	Alam, A.,Le, L.T.M.,Thompson, J.R. (deposition date: 2022-10-04, release date: 2022-12-21, Last modification date: 2023-02-15)
Primary citation	Le, L.T.M.,Thompson, J.R.,Dehghani-Ghahnaviyeh, S.,Pant, S.,Dang, P.X.,French, J.B.,Kanikeyo, T.,Tajkhorshid, E.,Alam, A. Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42:e111065-e111065, 2023 Cited by PubMed: 36484366 DOI: 10.15252/embj.2022111065 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation