8EO6

Crystal structure of metagenomic class A beta-lactamase precursor LRA-5 in complex with ceftazidime at 2.35 Angstrom resolution

8EO6 の概要

• エントリーDOI: 10.2210/pdb8eo6/pdb
• 分子名称: LRA-5, ACYLATED CEFTAZIDIME (3 entities in total)
• 機能のキーワード: beta-lactamase precursor, environmental resistome, soil metagenome, ceftazidime, oxyimino-cephalosporin, antimicrobial protein
• 由来する生物種: uncultured soil bacterium
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62893.80

構造登録者

Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (登録日: 2022-10-02, 公開日: 2023-10-04)

• 主引用文献: D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P.; Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions; to be published,

実験手法

X-RAY DIFFRACTION (2.35 Å)