8EO2

Lufaxin a bifunctional inhibitor of complement and coagulation

8EO2 の概要

• エントリーDOI: 10.2210/pdb8eo2/pdb
• 分子名称: Lufaxin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: complement, coagulation, sand fly, salivary, inhibitor, blood clotting
• 由来する生物種: Lutzomyia longipalpis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68654.15

構造登録者

Andersen, J.F.,Strayer, E.C. (登録日: 2022-10-01, 公開日: 2023-08-09, 最終更新日: 2024-02-21)

• 主引用文献: Andersen, J.F.,Lei, H.,Strayer, E.C.,Kanai, T.,Pham, V.,Pan, X.Z.,Alvarenga, P.H.,Gerber, G.F.,Asojo, O.A.,Francischetti, I.M.B.,Brodsky, R.A.,Valenzuela, J.G.,Ribeiro, J.M.C.; A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.; Blood, 141:3109-3121, 2023; PubMed: 36947859; DOI: 10.1182/blood.2022019359

実験手法

X-RAY DIFFRACTION (2.31 Å)