8ENJ

Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)

8ENJ の概要

• エントリーDOI: 10.2210/pdb8enj/pdb
• 分子名称: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide (2 entities in total)
• 機能のキーワード: cancer, jnk, leukemia, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53170.96

構造登録者

Park, H.,Mersal, K.I. (登録日: 2022-09-30, 公開日: 2023-10-18)

• 主引用文献: Mersal, K.I.,Abdel-Maksoud, M.S.,Ali, E.M.H.,Ammar, U.M.,Zaraei, S.O.,Haque, M.M.,Das, T.,Hassan, N.F.,Kim, E.E.,Lee, J.S.,Park, H.,Lee, K.H.,El-Gamal, M.I.,Kim, H.K.,Ibrahim, T.M.,Oh, C.H.; Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.; Eur.J.Med.Chem., 261:115779-115779, 2023; PubMed: 37776574; DOI: 10.1016/j.ejmech.2023.115779

実験手法

X-RAY DIFFRACTION (2.81 Å)