8EM8

Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165

8EM8 の概要

• エントリーDOI: 10.2210/pdb8em8/pdb
• 分子名称: cGMP-dependent protein kinase, unidentified peptide fragment, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, ... (5 entities in total)
• 機能のキーワード: sgc, cgmp-kinase, inhibitor, structural genomics, structural genomics consortium, transferase
• 由来する生物種: Plasmodium falciparum (isolate 3D7); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98630.55

構造登録者

Hutchinson, A.,Dong, A.,Seitova, A.,Bhanot, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (登録日: 2022-09-27, 公開日: 2022-11-02, 最終更新日: 2023-10-18)

• 主引用文献: Hutchinson, A.,Dong, A.,Seitova, A.,Bhanot, P.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165; To Be Published,

実験手法

X-RAY DIFFRACTION (2.54 Å)