8ELI

Broadly neutralizing antibody VRC34-combo.1 in complex with HIV fusion peptide (residue 512-519)

Summary for 8ELI

• Entry DOI: 10.2210/pdb8eli/pdb
• Descriptor: VRC34-combo.1 Fab Light chain, VRC34-combo.1 Fab Heavy chain, Fusion peptide, ... (4 entities in total)
• Functional Keywords: hiv, vrc34, fusion peptide, broadly neutralizing, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 48163.80

Authors

Xu, K.,Kwong, P.D. (deposition date: 2022-09-24, release date: 2023-09-27, Last modification date: 2024-02-14)

• Primary citation: Banach, B.B.,Pletnev, S.,Olia, A.S.,Xu, K.,Zhang, B.,Rawi, R.,Bylund, T.,Doria-Rose, N.A.,Nguyen, T.D.,Fahad, A.S.,Lee, M.,Lin, B.C.,Liu, T.,Louder, M.K.,Madan, B.,McKee, K.,O'Dell, S.,Sastry, M.,Schon, A.,Bui, N.,Shen, C.H.,Wolfe, J.R.,Chuang, G.Y.,Mascola, J.R.,Kwong, P.D.,DeKosky, B.J.; Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.; Nat Commun, 14:7593-7593, 2023; PubMed: 37989731; DOI: 10.1038/s41467-023-42098-5

Experimental method

X-RAY DIFFRACTION (1.49 Å)