8EL2

SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23

Summary for 8EL2

• Entry DOI: 10.2210/pdb8el2/pdb
• Descriptor: Fab ICO-hu23 Heavy Chain, Fab ICO-hu23 Light Chain, Spike protein S1, ... (6 entities in total)
• Functional Keywords: fab, sars-cov-2, receptor-binding domain, neutralizing antibody, antiviral protein, antiviral protein-immune system complex, antiviral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 149539.57

Authors

Besaw, J.E.,Kuo, A.,Morizumi, T.,Ernst, O.P. (deposition date: 2022-09-22, release date: 2023-07-19, Last modification date: 2023-10-25)

• Primary citation: Hermet, P.,Delache, B.,Herate, C.,Wolf, E.,Kivi, G.,Juronen, E.,Mumm, K.,Zusinaite, E.,Kainov, D.,Sankovski, E.,Virumae, K.,Planken, A.,Merits, A.,Besaw, J.E.,Yee, A.W.,Morizumi, T.,Kim, K.,Kuo, A.,Berriche, A.,Dereuddre-Bosquet, N.,Sconosciuti, Q.,Naninck, T.,Relouzat, F.,Cavarelli, M.,Ustav, M.,Wilson, D.,Ernst, O.P.,Mannik, A.,LeGrand, R.,Ustav Jr., M.; Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.; Plos Pathog., 19:e1011532-e1011532, 2023; PubMed: 37531329; DOI: 10.1371/journal.ppat.1011532

Experimental method

X-RAY DIFFRACTION (2.89 Å)