8EK9

Crystal structure of the class A carbapenemase CRH-1 in complex with avibactam at 1.4 Angstrom resolution

8EK9 の概要

• エントリーDOI: 10.2210/pdb8ek9/pdb
• 分子名称: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total)
• 機能のキーワード: class a carbapenemase, environmental lactamase, chromobacterium, dbo inhibitor, antimicrobial protein
• 由来する生物種: Chromobacterium haemolyticum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28952.84

構造登録者

Power, P.,Brunetti, F.,Ghiglione, B.,Guardabassi, L.,Gutkind, G.,Klinke, S. (登録日: 2022-09-20, 公開日: 2023-05-31, 最終更新日: 2023-10-25)

• 主引用文献: Brunetti, F.,Ghiglione, B.,Gudeta, D.D.,Gutkind, G.,Guardabassi, L.,Klinke, S.,Power, P.; Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases.; Antimicrob.Agents Chemother., 67:e0006123-e0006123, 2023; PubMed: 37272821; DOI: 10.1128/aac.00061-23

実験手法

X-RAY DIFFRACTION (1.4 Å)