8EI2

Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon Polypeptide

Summary for 8EI2

• Entry DOI: 10.2210/pdb8ei2/pdb
• Descriptor: Cullin-5, H314, N,N'-(1,4-phenylene)diacetamide (3 entities in total)
• Functional Keywords: e3 ligase, complex, stapled peptide, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 47036.74

Authors

Li, K.,Tokareva, O.S.,Thomson, T.M.,Verdine, G.L.,McGee, J.H. (deposition date: 2022-09-14, release date: 2023-10-25, Last modification date: 2023-11-15)

• Primary citation: Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H.; Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.; Nat Commun, 14:6992-6992, 2023; PubMed: 37914719; DOI: 10.1038/s41467-023-42395-z

Experimental method

X-RAY DIFFRACTION (2.8 Å)