8EGN
Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with ligand AZ-13643701
Summary for 8EGN
Entry DOI | 10.2210/pdb8egn/pdb |
Descriptor | UDP-N-acetylmuramate--L-alanine ligase, (1R,2S)-1-({4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)-2,3-dihydro-1H-inden-2-ol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ssgcid, murc, udp-n-acetylmuramoyl-l-alanine synthetase, cell wall biogenesis, peptidoglycan biosynthesis, structural genomics, seattle structural genomics center for infectious disease, ligase |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Total number of polymer chains | 2 |
Total formula weight | 68982.41 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-09-12, release date: 2022-09-28, Last modification date: 2023-10-18) |
Primary citation | Abendroth, J.,Dranow, D.M.,Hill, P.,Horanyi, P.S.,Lorimer, D.D.,Edwards, T.E. Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with ligand AZ-13643701 to be published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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