8EGI

X-ray structure of carbonmonoxy hemoglobin in complex with VZHE039-NO

Summary for 8EGI

Entry DOI	10.2210/pdb8egi/pdb
Descriptor	Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
Functional Keywords	hemoglobin, sickle cell disease, antisickling, nitric oxide, oxygen equilibrium curve, oxygen transport
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	65764.42
Authors	Donkor, A.K.,Musayev, F.N.,Safo, M.K. (deposition date: 2022-09-12, release date: 2022-11-16, Last modification date: 2023-10-18)
Primary citation	Huang, B.,Ghatge, M.S.,Donkor, A.K.,Musayev, F.N.,Deshpande, T.M.,Al-Awadh, M.,Alhashimi, R.T.,Zhu, H.,Omar, A.M.,Telen, M.J.,Zhang, Y.,McMahon, T.J.,Abdulmalik, O.,Safo, M.K. Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. Molecules, 27:-, 2022 Cited by PubMed: 36296435 DOI: 10.3390/molecules27206835 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation